Spotlight on elotuzumab in the treatment of multiple myeloma: the evidence to date
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منابع مشابه
Spotlight on elotuzumab in the treatment of multiple myeloma: the evidence to date
Despite advances in the treatment of multiple myeloma, it remains an incurable disease, with relapses and resistances frequently observed. Recently, immunotherapies, in particular, monoclonal antibodies, have become important treatment options in anticancer therapies. Elotuzumab is a humanized monoclonal antibody to signaling lymphocytic activation molecule F7, which is highly expressed on myel...
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Elotuzumab is one of the first two monoclonal antibodies that gained FDA approval for the treatment of multiple myeloma (MM). It targets SLAMF7, which is highly expressed in normal plasma and MM cells as well as natural killer (NK) cells. Elotuzumab demonstrated significant anti-myeloma activity in preclinical studies, and its mechanisms of action include mediating antibody-dependent cell-media...
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ژورنال
عنوان ژورنال: OncoTargets and Therapy
سال: 2016
ISSN: 1178-6930
DOI: 10.2147/ott.s94531